biochemistry of nucleic acids
Chemistry
for our midterm
Sample Data
| Front | what base pair is this? where are the major and minor grooves?
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| Back | G-C
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| Front | how do is the backbone conformation determined (think of the different angles)? (2) |
| Back | backbone conformation has 7 angles but there is steric hindrance that restrains the atoms the ribose pucker, phosphate charges, and base torsion (\(\chi\)) all profoundly impact 3D structure, affecting diameter and packaging |
| Front | what is this nucleobase? what impacts does it have on structure?
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| Back | m1A (adenine with methyl at atom 1)this introduces a partial positive charge on that nitrogen, which is extremely destabilizing to the helixloses an H-bond acceptor, destabilizing its bond to uracil or thymine |