| Text | What are the various advantages and disadvantages of VDRL and other Non-treponemal tests?{{c1::Advantages of Non-treponemal Tests:Recommended for monitoring response to treatmentCan be used to detect CSF antibodies in neurosyphilisReagin antibody becomes detectable 7-10 days after primary chancre or 3-5 weeks after acquiring the infectionSensitivity of non-treponemal tests: 78-85% in primary stage, 100% in secondary stage, 71-73% in late stageSpecificity: around 98-99%Disadvantages of Non-treponemal Tests:Biological false-positive (BFP) reactions may occur (incidence: 1-2%)Reagin antibodies may be found in unrelated diseases such as lepromatous leprosy, relapsing fever, malaria, viral hepatitis, HIV, pregnancy, and IV drug abusersProzone phenomena may lead to false negative results if antibody titer in patient's sera is highSensitivity of non-treponemal tests is low in late stage of syphilisVDRL-CSF is more reliable than VDRL test of serum for neurosyphilis detection}} |