MRCS part B surgical pathology
| Front | What is the adenoma carcinoma sequence? |
| Back | The majority of colorectal cancers are adenocarcinoma, mostly coming from benign ademona transformation which usually follows these steps:normal epithelium -> APC gene mutation -> hyperproliferation -> KRAS oncogene -> adenoma -> p53 tumour surpressor gene -> adenocarcioma |
| Front | What is the porcess of acute inflammation ? |
| Back | VasoconstrictionVasodilation + increased permeability Leucocyte margination and migration phagocytosis |
| Front | What are the characteristic features of B thalassaemia? |
| Back | Marrow hyperplasia - frontal bossing hyperslenism - low PLT, low WCC, anaemia Fe2+ overload - cardaic siderosis, endocrine disfunction, cirhosis |