| Front | DNA Repair - Mismatched Bases (G2) |
| Back | • Caused by DNA replication errors• Mutated hMLH1 or hMSH2 genes causes defective repair, resulting in hereditary nonpolyposis colorectal cancer, aka Lynch Syndrome |
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| Front | Topoisomerase II |
| Back | • Relieves supercoiling• The prokaryotic version (DNA gyrase) is targeted by fluoroquinolones and other DNA synthesis-inhibiting antibiotics• The eukaryotic version is targeted by anti-cancer drugs and other rapidly growing cells in G1 phase (epithelial cells) |
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| Front | Proteins Involved In DNA Replication |
| Back | • Helicase: Unwinds DNA• Single-Stranded Binding Proteins (SSB's): Stabilizing unwound strands• Primase: Synthesis of RNA Primers• DNA Polymerase (III in prokaryotes, alpha and delta in eukaryotes): Synthesis of leading and lagging strands• DNA Polymerase I: Removal and replacement of RNA in prokaryotes• RNase H: Removal of RNA primers in eukaryotes• DNA Polymerase delta: Replacement of RNA with DNA in eukaryotes• DNA Topoisomerase II (aka DNA gyrase in prokaryotes): fixing supercoiling• Telomerase: Synthesizing telomeres |
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